|
Glioma
|
0.700 |
GeneticVariation
|
disease |
UNIPROT |
|
|
|
|
Glioma
|
0.700 |
GeneticVariation
|
disease |
LHGDN |
Rarity of PTEN deletions and EGFR amplification in malignant gliomas of childhood: results from the Children's Cancer Group 945 cohort.
|
17328268 |
2006 |
|
Glioma
|
0.700 |
AlteredExpression
|
disease |
LHGDN |
The ARF4L transcript preferentially localized to the polysomal compartment after PTEN loss in glioma or activation of Akt in human astrocytes.
|
18240926 |
2008 |
|
Glioma
|
0.700 |
PosttranslationalModification
|
disease |
LHGDN |
We conclude that methylation of the PTEN promoter may represent an alternate mechanism by which PI3K signaling is increased in grade II and III gliomas as well as secondary GBMs, a finding that offers new therapeutic approaches in these patients.
|
17504928 |
2007 |
|
Glioma
|
0.700 |
AlteredExpression
|
disease |
LHGDN |
Protein expression of platelet-derived growth factor receptor correlates with malignant histology and PTEN with survival in childhood gliomas.
|
18519768 |
2008 |
|
Glioma
|
0.700 |
AlteredExpression
|
disease |
LHGDN |
PTEN gene expression was suppressed in the glioma, which is related to the clinical-pathological results.
|
17000554 |
2006 |
|
Glioma
|
0.700 |
GeneticVariation
|
disease |
LHGDN |
Malignant glioma: the involvement of loss of allelic heterozygosity and PTEN mutations in a group of Malay patients.
|
16124450 |
2005 |
|
Glioma
|
0.700 |
AlteredExpression
|
disease |
LHGDN |
PTEN down regulates AP-1 and targets c-fos in human glioma cells via PI3-kinase/Akt pathway.
|
17235455 |
2007 |
|
Glioma
|
0.700 |
GeneticVariation
|
disease |
LHGDN |
Since then, important progress has been made with respect to the understanding of the role of the Pten protein in the normal development of the brain as well as in the molecular pathogenesis of human gliomas.
|
12084351 |
2002 |
|
Glioma
|
0.700 |
AlteredExpression
|
disease |
LHGDN |
Regulation of c-Met-dependent gene expression by PTEN.
|
15516982 |
2004 |
|
Glioma
|
0.700 |
GenomicAlterations
|
disease |
CGI |
|
|
|
|
Glioma
|
0.700 |
CausalMutation
|
disease |
CGI |
|
|
|
|
Glioma
|
0.700 |
Biomarker
|
disease |
CTD_human |
The reported patient, in addition to glioma, had suffered from benign meningioma in the past but did not show any clinical signs of Cowden disease or other hereditary diseases typically associated with PTEN germline mutations.
|
12085208 |
2002 |
|
Glioma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Preclinical therapeutic efficacy of a novel blood-brain barrier-penetrant dual PI3K/mTOR inhibitor with preferential response in PI3K/PTEN mutant glioma.
|
28423515 |
2017 |
|
Glioma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
A new tumor suppressor gene PTEN/MMAC1 was recently isolated at chromosome 10q23 and found to be inactivated by point mutation or homozygous deletion in glioma, prostate and breast cancer.
|
9671402 |
1998 |
|
Glioma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
In this study we compared the intratumoral and circulating EPCs of glioma patients for a set of common glioma genotypical aberrations (amplification of EGFR; deletion of PTEN and aneusomy of chromosomes 7 and 10).
|
23254765 |
2013 |
|
Glioma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Because PTEN negatively regulates on the downstream effects of phosphatidylinositol-3-kinase (PI3-K), we hypothesized that the loss of PTEN/MMAC1 and the activation of RAS may be largely equivalent because RAS is a known positive upstream regulator of PI3-K. We expanded our previous survey of PTEN/MMAC1 mutations and analyzed the RAS status of 53 cutaneous melanoma cell lines, 18 glioma cell lines, and 17 uncultured cutaneous melanoma metastasis.
|
10766161 |
2000 |
|
Glioma
|
0.700 |
PosttranslationalModification
|
disease |
BEFREE |
Forty-five LGG tumor specimens from newly diagnosed patients were analyzed for methylation of the putative 5'-promoter region of PTEN using methylation-specific PCR as well as phosphorylation of S6 and PRAS40 and expression of PTEN protein using immunohistochemistry.
|
19705067 |
2010 |
|
Glioma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
PTEN/PI3K/Akt pathway regulates the side population phenotype and ABCG2 activity in glioma tumor stem-like cells.
|
19265662 |
2009 |
|
Glioma
|
0.700 |
Biomarker
|
disease |
BEFREE |
The ARF4L transcript preferentially localized to the polysomal compartment after PTEN loss in glioma or activation of Akt in human astrocytes.
|
18240926 |
2008 |
|
Glioma
|
0.700 |
Biomarker
|
disease |
BEFREE |
This symbiotic glioma-macrophage interplay provides therapeutic targets specifically for PTEN-deficient GBM.
|
31185211 |
2019 |
|
Glioma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Tangeretin induces cell cycle arrest and apoptosis through upregulation of PTEN expression in glioma cells.
|
27261630 |
2016 |
|
Glioma
|
0.700 |
Biomarker
|
disease |
BEFREE |
Using the C6 glioma cell line, which does not express measurable amounts of PTEN protein and in which in vitro invasiveness is MMP dependent, the authors determined that in vitro glioma cell invasiveness was significantly reduced when cells were preincubated overnight with LY294002 or wortmannin, two specific inhibitors of PI 3-K signaling.
|
11565871 |
2001 |
|
Glioma
|
0.700 |
Biomarker
|
disease |
BEFREE |
The authors introduced wild-type PTEN complementary DNA into four human glioma cell lines (T98G, U-251MG, U-87MG, and A172) containing endogenous aberrant PTEN alleles.
|
10541240 |
1999 |
|
Glioma
|
0.700 |
PosttranslationalModification
|
disease |
BEFREE |
Introduction of PTEN gene in glioma cell lines markedly reduced the levels of Rac-GTP and Cdc42-GTP, activated forms of these small GTP-binding proteins, and decreased the phosphorylation levels of focal adhesion kinase.
|
16773187 |
2006 |